Gene Ontology
What is gene ontology?
Gene ontology is a controlled vocabulary used that can be applied to all eukaryotic cellular functions and pathways. It uses three ontological categories: biological process, molecular function and cellular component. Biological process refers to the end goal to which the gene of inquiry contributes, examples include "cell growth" or "pyrimidine metabolism." Molecular function is defined as the biochemical activity of the gene, which may include information about specific ligands or binding structures. Examples include "enzyme" or "adenylate cyclase." Lastly, cellular component refers to the localization of the active gene product, which might be "ribosome" or "nuclear membrane" [1]. Gene ontology can be identified through databases which search a finite number of gene ontology terms to find those related to a known gene product. These terms are directly related to information obtained through primary research, but provide a solid foundation for understanding the genetic, molecular and biochemical capacities of a gene. |
MEFV Gene Ontology
Biological Process
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Molecular Function
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Analysis
Gene ontology provides a snapshot of biochemical, genetic and molecular roles of a gene product within the cell. This provides an excellent avenue to explore new information and to learn more about a gene of interest. For MEFV, Gene ontology confirms its cytological role as predicted from known protein domains, protein interactions and its regulation of the inflammasome. References [1] Ashburner, M, et al. (2000) Gene Ontology: tool for the unification of biology Nat Genet. 25(1):25-29. |